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81.
Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism 总被引:4,自引:0,他引:4
Oxytocin (OT), a nonapeptide produced in the paraventricular and the supraoptical nuclei in the hypothalamus has a wide range of effects in the body. However, the role of OT on the gastrointestinal (GI) tract has to be settled. OT may participate in the regulation of motility, secretion, blood flow, cell turnover and release of neurotransmitters and/or peptides in the GI tract, possesses antisecretory and antiulcer effects, facilitates wound healing and is involved in the modulation of immune and inflammatory processes. The present work was conducted to assess the possible therapeutic effects of OT against the acetic acid-induced colonic injury in the rat. METHODS: Colitis was induced by intracolonic administration of acetic acid (5%) in Sprague-Dawley rats (200-250 g). Either saline or OT (0.5 mg/kg) was injected subcutaneously, immediately after the induction of colitis and repeated two times a day for 4 days. On the 4th day, rats were decapitated and distal 8 cm of the colon were removed for the macroscopic and microscopic damage scoring, determination of tissue wet weight index (WI), malondialdehyde (MDA) levels, an end product of lipid peroxidation; glutathione (GSH) levels, a key antioxidant; and myeloperoxidase (MPO) activity, as an indirect index of neutrophil infiltration. Colonic collagen content, as a fibrosis marker was also determined. Lactate dehydrogenase (LDH) and tumor necrosis factor-alpha (TNF-alpha) levels were assayed in serum samples. In the acetic acid-induced colitis, macroscopic and microscopic damage scores, WI, MDA and MPO levels were significantly increased, while GSH levels were decreased when compared to control group (p <0.05-<0.001). Treatment with OT abolished the colitis-induced elevations in damage scores, WI, MDA and MPO levels and restored the GSH levels (p <0.05-0.001). Similarly, acetic acid increased the collagen content of colonic tissues and OT-treatment reduced this value to the level of the control group. Serum LDH and TNF-alpha levels were also elevated in the acetic acid-induced colitis group as compared to control group, while this increase was significantly decreased by OT treatment. The results suggest that OT, which improves the antioxidative state of the colonic tissue and ameliorates oxidative colonic injury via a neutrophil-dependent mechanism, requires further investigation as a potential therapeutic agent in colonic inflammation. 相似文献
82.
Ozer C Gönül B Elmas C Erdoüan D Ercan ZS 《Molecular and cellular biochemistry》2005,280(1-2):151-157
Dexfenfluramine is one of the anorectic drugs that suppresses food intake which acts via inhibition of reuptake of serotonin
into brain terminal. Gastrointestinal tract is the main source of peripheral serotonin which is involved in the regulation
of gastrointestinal motility. During the use of anorectic drugs, the antioxidant defence is affected especially by reactive
oxygen species.
The purpose of this study to search: The effect of dexfenfluramine on serotonin levels of ileum and the effect of dexfenfluramine
on ileal contractility and oxidative stress.
Materials and Methods: Twenty-two adult male Swiss-albino mice were divided two groups (1) Control, (2) Dexfenfluramine treated
(i.p. twice a day 0.2 mg kg−1 in 0.2 ml saline solution for 7 days). Animal body weights were recorded at the beginning and at the end of the experimental
period. Ileum tissues contractile responses to different concentrations of KCl and acethycholine were recorded on polygraph.
In the meantime ileal tissue malondialdehyde, a product of lipid peroxidation, and glutathione, endogenous antioxidant levels
were assessed by spectrophotometric methods. Ileal tissue serotonin level determined by immunohistochemical method. Body weights
decrease and ileal contractile response of acethycholine increased significantly by dexfenfluramine treatment. Meanwhile,
ileum glutathione levels decreased and malondialdehyde levels increased in dexfenfluramine treated group. Immunohistochemical
detection showed that ileal serotonin levels increased by dexfenfluramine treatments.
As a conclusion, there is a relationship between increased ileal contractility and oxidant status in dexfenfluramine treated
animals. These effects can be related by increased serotonin levels which is induced by dexfenfluramine in ileum. (Mol Cell
Biochem xxx: 151–157, 2005) 相似文献
83.
84.
Ercan Varol Selahattin Akcay I. Hakki Ersoy Mehmet Ozaydin Banu Kale Koroglu Simge Varol 《Biological trace element research》2010,133(2):121-127
Sixty-three patients with endemic fluorosis (36 males/27 females; mean age 33.9 ± 8.6 years) and 45 age-, sex-, and body mass
index-matched healthy controls (30 males/15 females; mean age 32.7 ± 8.8 years) were included in this study. Aortic stiffness
indices, aortic strain (AS), aortic distensibility (AD), and aortic strain index (ASI) were calculated from the aortic diameters
measured by echocardiography and blood pressure obtained by sphygmomanometry. The urine fluoride levels of fluorosis patients
were significantly higher than control subjects as expected (1.9 ± 0.1 mg/l vs. 0.4 ± 0.1 mg/l, respectively; P < 0.001). AS and AD were significantly lower in fluorosis patients than in the controls (for AS 5.3 ± 3.6 vs. 8.0 ± 3.4%;
P < 0.001 and for AD 0.2 ± 0.1 vs. 0.3 ± 0.1 cm2 dyn−1 10−3; P < 0.001, respectively). In contrast, signicantly higher ASI was observed in fluorosis patients than in the controls (3.4 ± 0.6
vs. 3.0 ± 0.4; P < 0.001, respectively). The results of our study demonstrate that elastic properties of ascending aorta are impaired in patients
with endemic fluorosis. 相似文献
85.
Endometrial gene expression profiling of recurrent implantation failure after in vitro fertilization
Albayrak İrem Gülfem Azhari Fatemeh Çolak Ezgi Nur Balcı Burçin Karamustafaoğlu Ülgen Ege Sezerman Uğur Baştu Ercan Günel Tuba 《Molecular biology reports》2021,48(6):5075-5082
Molecular Biology Reports - Recurrent implantation failure (RIF) is diagnosed when good-quality embryos repeatedly fail to implant after transfer in several in vitro fertilization (IVF) treatment... 相似文献
86.
Oguz Tuncer Erdal Peker Nihat Demir Sinan Akbayram Ercan Kirimi 《The Journal of membrane biology》2013,246(7):525-528
We compared spectrophotometric analysis of the umbilical cords of infants with meconium aspiration syndrome (MAS) or with meconium-stained amniotic fluid (MSAF) and healthy infants. In a prospective study, 15 infants with MAS and 37 infants with MSAF were enrolled. Twenty healthy infants formed a control group. The absorption peak of umbilical cords with meconium was significantly higher in the infants with MAS or MSAF than in controls. Spectrophotometric analysis of the umbilical cords with meconium may be useful to identify developed neonates with MAS or MSAF. 相似文献
87.
88.
Germec Mustafa Gürler Hilal Nur Ozcan Ali Erkan Selime Benemir Karahalil Ercan Turhan Irfan 《Bioprocess and biosystems engineering》2020,43(2):217-232
Bioprocess and Biosystems Engineering - The goals of this study were to optimize the medium formulation for enhanced production of Aspergillus niger inulinase using Plackett–Burman Design... 相似文献
89.
Ersoy IH Koroglu BK Varol S Ersoy S Varol E Aylak F Tamer MN 《Biological trace element research》2011,143(2):619-624
Although there are many studies on effect of fluoride on trace elements in experimental animals, few studies exist on serum
trace elements levels in patients with endemic fluorosis. We aimed to determine the serum levels of trace elements including
serum copper (Cu), zinc (Zn), and serum levels of minerals including calcium (Ca), phosphorus (P), magnesium (Mg), sodium
(Na), potassium (K) in patients with endemic fluorosis. The study group consisted of 30 patients with endemic fluorosis (17
females, 13 males, mean age 33.53 ± 9.85 years). An age, gender, and body mass index matched 30 healthy volunteers comprised
control group (21 females, ten males with a mean age 33.93 ± 7.39 years). Urine fluoride levels of chronic fluorosis patients
were significantly higher than that of control subjects as expected (1.92 ± 0.10 mg/l vs. 0.41 ± 0.09 mg/l, respectively;
P < 0.001). Serum Cu levels (89.14 ± 16.77 μg/dL vs. 102.69 ± 25.04 μg/dL, respectively, P = 0.017), serum Zn levels (77.98 ± 20.58 μg/dL vs. 94.57 ± 35.87μg/dL, respectively, P = 0.032), and serum Mg levels (1.92 ± 0.18 mg/dL vs. 2.07 ± 0.31 mg/dL, respectively, p = 0.022) was significantly lower in chronic fluorosis patients than in controls. There were no statistically significant
differences between the fluorosis group and control group with respect to serum levels of Na, K, Ca, and P. We concluded that
chronic fluorosis is associated with reduced serum levels of Cu, Zn, and Mg. 相似文献
90.
Morphine is widely used to treat chronic pain, however its utility is hindered by the development of tolerance to its analgesic effects. The aim of this study was to investigate effects of fluoxetine, a specific serotonin (5-HT) reuptake inhibitor, and LY 367265, an inhibitor of the 5-HT transporter and 5-HT2A receptor antagonist, on tolerance induced to the analgesic effect of morphine in rats. The study was carried out on male Wistar Albino rats (weighing 170-190 g). To constitute morphine tolerance, animals received morphine (50 mg/kg; s.c.) once daily for 3 days. After last dose of morphine, injected on day 4, morphine tolerance was evaluated. The analgesic effects of fluoxetine (10 mg/ kg; i.p.), LY 367265 (3 mg/kg; i.p.) and morphine were considered at 30-min intervals by tail-flick and hot-plate tests. The results showed that fluoxetine and LY 367265 significantly attenuated the development and expression of morphine tolerance. The maximal antinociceptive effects were obtained 30 min after administration of fluoxetine and 60 min after administration of LY 367265. In conclusion, we observed that co-injection of morphine with fluoxetine and LY 367265 increased the analgesic effects of morphine and delayed development of tolerance to morphine analgesia. 相似文献